Engineering CAR T cells to deliver endogenous RNA wakes solid tumors to respond to therapy
A new study shows CAR T cells expressing RN7SL1 can activate the body’s natural immune cells against difficult-to-treat cancers.
Mindfully Curated
A new study shows CAR T cells expressing RN7SL1 can activate the body’s natural immune cells against difficult-to-treat cancers.
Researchers demonstrated that the microscopic worm C. elegans uses a retrotransposon called Cer1 to transfer a learned behavior (avoidance of a pathogenic bacterium) between worms.
Using environmental DNA scans of Appalachian streams, researchers found that the effects of mountaintop coal mining in West Virginia are even more widespread than previously reported: Streams from heavily mined watersheds harbor 40% fewer species than …
Vaccinations against human papillomavirus (HPV), a major cause of throat and back of mouth cancers, are expected to yield significant reductions in the rates of these cancers in the U.S., but will not do so until after 2045, according to a new modeling…
A new analysis suggests that, in order to boost freedoms and protect against overwhelming new waves of COVID-19, the pace at which restrictions to reduce spread are lifted must be directly tied to the pace of vaccination.
Medical researchers report that melanoma formation depends on something called ‘oncogenic competence,’ which is the result of a collaboration between the DNA mutations in a cell and the particular set of genes that are turned on in that cell. Cells tha…
While studying the behavior of electrons in iron-based superconducting materials, researchers observed a strange signal relating to the way electrons are arranged. The signal implies a new arrangement of electrons the researchers call a nematicity wave…
Recent dog breeding practices have loaded up cavalier King Charles spaniels with disease-causing mutations, including variants linked to the common heart condition, myxomatous mitral valve disease (MMVD), according to new findings.
The Very Large Array Sky Survey gave astronomers the first clue that ultimately revealed a dramatic story — the remnant of a star that exploded long ago had plunged into the core of its companion star causing it, too, to explode as a supernova.
The Indian wolf could be far more endangered than previously recognized, say first scientists to sequence its genome. Indian wolves could also represent the most ancient surviving lineage of wolves.
New experiments using trapped one-dimensional gases — atoms cooled to the coldest temperatures in the universe and confined so that they can only move in a line — fit with the predictions of the recently developed theory of ‘generalized hydrodynamics.’
Parents and educators have long fretted over the amount of time children and teenagers spend online. But when it comes to screen time, the problem is not so much the number of hours spent online, but the quality of online interactions, particularly und…
Rhesus macaques naturally exposed to wildfire smoke early in pregnancy had an increased rate of miscarriage, according to new research.
Bird dispersal movements are thought to depend on complex demographic and genetic factors. Researchers show that there may be a simpler explanation: bird dispersal distances depend on the morphology and flight efficiency of the wings. Bird populations …
U.S. jails function as ‘infectious disease incubators’ for surrounding communities, as high rates of viral transmission cause COVID-19 cases to multiply and ‘boomerang’ back to communities. A new national study shows that reducing jail populations, mas…
A new, automated, artificial intelligence-based algorithm can learn to read patient data from electronic health records. In a side-by-side comparison, scientists showed that their method accurately identified patients with certain diseases as well as t…
Many arboreal lizards leap and glide from tree to tree, but what if they can’t glide to a gentle, four-point landing? Researchers documented many such leaps of the common house gecko, and found that they often hit trees headfirst and rebounded violentl…
Researchers have discovered geologic evidence that unusually large earthquakes and tsunamis from the Tokyo region — located near tectonic plate boundaries that are recognized as a seismic hazard source — may be traceable to a previously unconsidered …
Researchers have made a tiny camera, held together with ‘molecular glue’ that allows them to observe chemical reactions in real time.
An analysis of more than 20,000 individual medical records suggests that a form of heart valve disease thought to be relatively benign during pregnancy may put women at risk for serious bleeding, high blood pressure, organ damage and other complication…